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Early MM detection could allow therapeutic interventions at a potentially treatable stage. There is a great interest in blood biomarkers and on their potential use in screening for the early detection of MM.
Nevertheless, so far, the studies on this topic have led to variable results. There are no satisfactory results, and no marker seems to be eligible in surveillance of subject at risk of MM when used alone.
In the future the combination of different markers might help to distinguish mesothelioma from benign asbestos-related diseases and asbestos-exposed subjects. Keywords This is a preview of subscription content, log in to check access. References 1.
Prevention of asbestos-related disease in countries currently using asbestos. Malignant mesothelioma: facts, myths, and hypotheses. J Cell Physiol.
DeVita Hellman and Rosenberg’s Cancer 10th Edition
Am J Pathol. Gazdar AF, Carbone M. Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus Clin Lung Cancer. Simian virus the link with human malignant mesothelioma is well established.
Anticancer Res. PubMed Google Scholar 6.
Carbone M. Simian virus 40 and human tumors: it is time to study mechanisms. J Cell Biochem. Asbestos is not just asbestos: an unrecognised health hazard. Lancet Oncol. Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet. BAP1 and cancer. Nat Rev Cancer. Benign and malignant mesothelioma. Google Scholar Biological markers in epidemiology. New York: Oxford University Press; Naglova H, Bucova M.
HMGB1and its physiologicaland pathological roles. Bratisl Lek Listy. PubMed Google Scholar HMGB1 in cancer: good, bad, or both?
Clin Cancer Res. CrossRef Google Scholar Annu Rev Immunol. Biochem Biophys Res Commun. Cancer Res. Serum HMGB1 as a diagnostic marker for malignant peritoneal mesothelioma. Now in National Gallery in Washington, D.
Screening Issues in Exposed Subjects and Early Diagnosis
From the midth century onward, the legend was widely disseminated and believed. Joan was used as an exemplum in Dominican preaching. The book contains the following account of the female Pope: Pope John VIII: John, of English extraction, was born at Mentz Mainz and is said to have arrived at popedom by evil art; for disguising herself like a man, whereas she was a woman, she went when young with her paramour, a learned man, to Athens, and made such progress in learning under the professors there that, coming to Rome, she met with few that could equal, much less go beyond her, even in the knowledge of the scriptures; and by her learned and ingenious readings and disputations, she acquired so great respect and authority that upon the death of Pope Leo IV as Martin says by common consent she was chosen pope in his room.
Clement's her travail came upon her, and she died upon the place, having sat two years, one month, and four days, and was buried there without any pomp.
This story is vulgarly told, but by very uncertain and obscure authors, and therefore I have related it barely and in short, lest I should seem obstinate and pertinacious if I had admitted what is so generally talked.
I had better mistake with the rest of the world, though it be certain, that what I have related may be thought not altogether incredible.
Pope Joan giving birth. Giovanni Boccaccio wrote about her in De Mulieribus Claris This statue had never been mentioned by any earlier writer anywhere; presumably it was an actual statue that came to be taken to be of the female pope.
A lateth-century edition of the Mirabilia Urbis Romae, a guidebook for pilgrims to Rome, tells readers that the female Pope's remains are buried at St. At his trial in , Jan Hus argued that the Church does not necessarily need a pope, because, during the pontificate of "Pope Agnes" as he also called her , it got on quite well.
Hus's opponents at this trial insisted that his argument proved no such thing about the independence of the Church, but they did not dispute that there had been a female pope at all. During the Reformation[ edit ] In , Florimond de Raemond , a magistrate in the parlement de Bordeaux and an antiquary , published his first attempt to deconstruct the legend, Erreur Populaire de la Papesse Jeanne also subsequently published under the title L'Anti-Papesse.
The tract applied humanist techniques of textual criticism to the Pope Joan legend, with the broader intent of supplying sound historical principles to ecclesiastical history, and the legend began to come apart, detail by detail.
Raemond's Erreur Populaire went through successive editions, reaching a fifteenth as late as The famous bust of her, inscribed Johannes VIII, Femina ex Anglia, which had been carved for the series of papal figures in the Duomo di Siena about and was noted by travelers, was either destroyed or recarved and relabeled, replaced by a male figure, that of Pope Zachary.
According to Pierre Gustave Brunet ,  Various authors, in the 16th and 17th centuries, occupied themselves with Pope Joan, but it was from the point of view of the polemic engaged in between the partisans of Lutheran or Calvinist reform and the apologists of Catholicism. Even in the 19th century, authors such as Ewaldus Kist and Karl Hase discussed the story as a real occurrence.
Modern analysis and critique[ edit ] The Popess tarot card from the Visconti-Sforza tarot deck, c. Coins exist which bear both the image of Benedict III and of Emperor Lothair , who died 28 September ; therefore Benedict must have been recognized as pope before the last-mentioned date.
All these witnesses prove the correctness of the dates given in the lives of Leo IV and Benedict III, and there was no interregnum between these two Popes, so that at this place there is no room for the alleged Popess. For example, Photios I of Constantinople , who became Patriarch in and was deposed by Pope Nicholas I in , was an enemy of the pope.
He vehemently asserted his own authority as patriarch over that of the pope in Rome, and would have made the most of any scandal of that time regarding the papacy; but he never mentions the story once in any of his voluminous writings.
Indeed, at one point he mentions "Leo and Benedict, successively great priests of the Roman Church". De Mailly's account was acknowledged by his companion Stephen of Bourbon.
Peter Stanford , a British writer and former editor of The Catholic Herald , concluded in The Legend of Pope Joan: In Search of the Truth "Weighing all th[e] evidence, I am convinced that Pope Joan was an historical figure, though perhaps not all the details about her that have been passed on down the centuries are true".
Philip Jenkins in The New Anti-Catholicism: The Last Acceptable Prejudice suggests that the periodic revival of what he calls this "anti-papal legend" has more to do with feminist and anti-Catholic wishful thinking than historical accuracy.
While his mother and Marena welcome him and celebrate him as a "friend" of man, the old Prince and Bambi pity him. Marena becomes his mate, but several weeks later Gobo is killed when he approaches a hunter in the meadow, falsely believing the halter he wore would keep him safe from all men.
As Bambi continues to age into young adulthood, he begins spending most of his time alone, including avoiding Faline though he still loves her in a melancholic way. Several times he meets with the old Prince who teaches him about snares , shows him how to free another animal from one, and encourages him not to use trails, to avoid the traps of men. When Bambi is later shot by a hunter, the Prince shows him how to walk in circles to confuse the man and his dogs until the bleeding stops, then takes him to a safe place to recover.
They remain together until Bambi is strong enough to leave the safe haven again. When Bambi has grown gray and is "old", the old Prince shows him that man is not all-powerful by showing him the dead body of a man who was shot and killed by another man.
When Bambi confirms that he now understands that "He" is not all-powerful, and that there is "Another" over all creatures, the stag tells him that he has always loved him and calls him "my son" before leaving to die.
At the end of the novel, Bambi meets with twin fawns who are calling for their mother and he scolds them for not being able to stay alone. After leaving them, he thinks to himself that the girl fawn reminded him of Faline, and that the male was promising and that Bambi hoped to meet him again when he was grown. Publication history[ edit ] Salten, himself an avid hunter,  penned Bambi: Eine Lebensgeschichte aus dem Walde after World War I , targeting an adult audience.
A new English translation by Hannah Correll was published in Copyright dispute[ edit ] When Salten originally published Bambi in , he did so under Germany's copyright laws, which required no statement that the novel was copyrighted. In the republication, he did include a United States copyright notice, so the work is considered to have been copyrighted in the United States in After Salten's death in , his daughter Anna Wyler inherited the copyright and renewed the novel's copyrighted status in U.
In , she formulated three agreements with Disney regarding the novel's rights. Upon her death in , the rights passed to her husband, Veit Wyler, and her children, who held on to them until when he sold the rights to the publishing house Twin Books. Twin Books and Disney disagreed on the terms and validity of Disney's original contract with Anna Wyler and Disney's continued use of the Bambi name. Disney argued that because Salten's original publication of the novel did not include a copyright notice, by American law it was immediately considered a public domain work.After the stags leave, the fawns learn that those were their fathers, but that the fathers rarely stay with or speak to the females and young.
Agatha Christie , forfatterinde. Clin Cancer Res.
Albanian Writers. Over the course of the summer, his mother teaches him about the various inhabitants of the forest and the ways deer live.
Mid-winter, hunters enter the forest, killing many animals including Bambi's mother. Diagnostic and prognostic utilities of humoral fibulin-3 in malignant pleural mesothelioma: evidence from a meta-analysis. Bratisl Lek Listy. It has an internal building area of 97 square metres.
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